![]() Essentially, the mice are exposed to two identical objects in specific locations. The researchers tested the memory of the mice using an object memory location task that has been shown to specifically require the dorsal hippocampus. Because memory formation is better during the day in many organisms, we were interested in understanding the molecular mechanisms that link the circadian clock to memory.” “This system also influences day/night oscillations in other regions of the brain, including the dorsal hippocampus, one of the regions where memories are formed. Subscribe for FREE“The circadian system, which regulates physiological changes in our bodies across the 24-hour day, is shared across most organisms and is primarily controlled in a region of the brain called the superchiasmatic nucleus,” said Janine Kwapis, assistant professor of biology in the Eberly College of Science at Penn State and leader of the research team. Subscribe to Technology Networks’ daily newsletter, delivering breaking science news straight to your inbox every day. ![]() “The circadian system, which regulates physiological changes in our bodies across the 24-hour day, is shared across most organisms and is primarily controlled in a region of the brain called the superchiasmatic nucleus,” said Janine Kwapis, assistant professor of biology in the Eberly College of Science at Penn State and leader of the research team. Understanding these mechanisms and the influence of time of day on memory formation could help researchers to determine how and when people learn best.Ī paper describing the research appears online in journal Neuropsychopharmacology. The research demonstrates a link between the circadian system and memory formation and begins to piece together the molecular mechanisms that help form and keep memories. Experiments showed that the gene, Period 1, which is known to be involved in the body’s circadian clock, is crucial for improved daytime memory performance. ![]() Researchers at Penn State tested the memory of mice during the day and at night, then identified genes whose activity fluctuated in a memory-related region of the brain in parallel with memory performance. ![]() A gene that plays a key role in regulating how bodies change across the 24-hour day also influences memory formation, allowing mice to consolidate memories better during the day than at night. ![]()
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